Kiryluk Lab

Selected Publications

Liu L., Zhu L., Monteiro-Martins S., et al Genome-wide studies define new genetic mechanisms of IgA vasculitis MedRxiv. doi: https://doi.org/10.1101/2024.10.10.24315041.

Khan A., Kiryluk K. Polygenic scores and their applications in kidney disease. Nature Reviews Nephrology. Sept 13, 2024.

Wang C., Wang TY., Kiryluk K., et al. Genome-wide discovery for biomarkers using quantile regression at biobank scale. Nature Communications. July 31, 2024.

Elliott M.D., Vena M., Marasa M., et al. Increased risk of kidney failure in patients with genetic kidney disorders. The Journal of Clinical Investigation. September 3, 2024.

Batal I., Watts AJB., Gibier JB., et al. Pre-transplant anti-nephrin antibodies are specific predictors of recurrent diffuse podocytopathy in the kidney allograft. Kidney International 2024: S0085-2538(24)00546-5. doi: 10.1016/j.kint.2024.07.022.

Zanoni F., Nougat Y.D., Obayemi J.E., et al. Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in two multiethnic urban cohorts. Am J Transplant. Feb 06, 2024. See related editorial.

Khan A., Shang N., Nestor J., et al. Polygenic risk alters the penetrance of monogenic kidney disease. Nature Communications. Dec 14, 2023.

Kiryluk K., Sanchez-Rodriguez E., Zhou XJ., et al. GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy. Nature Genetics. June 19, 2023. Press

Yang ZK., Wang C., Liu LX., et al. CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses Nature Genetics. May 11, 2023.

Liu L., Khan A., Sanchez-Rodriguez E., et al. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. Nature Communications. November 11, 2022.

Khan A., Turchin M., Patki A., et al. Genome-wide polygenic score with APOL1 risk genotypes predicts chronic kidney disease across major continental ancestries. Nature Medicine. 2022. doi.org/10.1101/2021.10.25.21265398. Press. Nature Research Briefing.

Xu K., Shang N., Levitman A., et al. Elevated NGAL is Associated with the Severity of Kidney Injury and Poor Prognosis of Patients with COVID-19. Kidney International Reports October 7, 2021. doi.org/10.1016/j.ekir.2021.09.005. Press. More Press

Khan A., Shang N., Petukhova., et al. Medical Records-Based Genetic Studies of the Complement System. J Am Soc Nephrol. 2021:ASN.2020091371. doi: 10.1681/ASN.2020091371. Editorial

Shang N., Khan A., Polubriaginof F., et al. Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies. NPJ Digit Med. 2021;4(1):70. doi: 10.1038/s41746-021-00428-1. Press

Povysil G., Butler-Laporte G., Shang N., et al. Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19. J Clin Invest. 2021;147834. doi: 10.1172/JCI147834. Editorial

Sanchez-Rodriguez E., Southard CT., Kiryluk K. GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid Sensitive Nephrotic Syndrome. Clin J Am Soc Nephrol. 2021;16(3):485-466:doi: 10.2215/CJN.14031119

Xie J., Liu L., Mladkova N., et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nature Communications 11, 1600 (2020).

Xu D., Wang C., Kiryluk K., et al. Co-localization between Sequence Constraint and Epigenomic Information Improves Interpretation of Whole-Genome Sequencing Data. Am J Hum Genet. 2020;106(4):513-524. doi: 10.1016/j.ajhg.2020.03.003.

Zanoni F., Kiryluk K. Genetic background and transplantation outcomes: insights from genome-wide association studies. Curr Opin Organ Transplant. 2020 Feb;25(1):35-41.

Neugut YD., Mohan S., Gharavi AG., et al. Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant Ann Intern Med. 2019. doi: 10.7326/M19-1389.

Steers NJ., Li Y., Drace Z., et al. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. N Engl J Med. 2019 May 16;380(20):1918-1928. Press

Kiryluk K., Goldstein DB., Rowe JW., et al. Precision Medicine in Internal Medicine. Ann Intern Med. 2019. doi: 10.7326/M18-0425. Press

Groopman EE., Marasa M., Cameron-Christie S., et al. Diagnostic Utility of Exome Sequencing for Kidney Disease. N Engl J Med. 2019;380(2):142-151. doi: 10.1056/NEJMoa1806891. Press

Verbitsky M., Westland R., Perez A., et al. The copy number variation landscape of congenital anomalies of the kidney and urinary tract. Nature Genetics. 2019;51(1):117-127. doi: 10.1038/s41588-018-0281-y.

Backenroth D., He Z., Kiryluk K., et al. FUN-LDA: A latent Dirichlet allocation model for predicting tissue-specific functional effects of noncoding variation. Am J Hum Genet. 2018;102(5):920-942.

Polubriaginof FCG., Vanguri R., Quinnies K., et al. Disease Heritability Inferred from Familial Relationships Reported in Medical Records. Cell 2018. doi:https://doi.org/10.1016/j.cell.2018.04.032. Press

Kiryluk K., Bomback AS., Cheng YL., et al. Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics. Semin Nephrol. 2018 Jan;38(1):40-51. doi: 10.1016/j.semnephrol.2017.09.006.

Kiryluk K., Li Y., Moldoveanu Z., et al. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway. PLoS Genetics 2017; doi: https://doi.org/10.1371/journal.pgen.1006609.

Kiryluk K., Novak J. The Genetics and immunobiology of IgA nephropathy. J Clin Invest. 2014;124(6):2325-32.

Kiryluk K., Li Y., Scolari F., et al. Novel GWAS Loci for IgA Nephropathy Implicate the Intestinal Immunity Network. Nature Genetics. 2014; 46(11):1187-96.

Kiryluk K., Novak J., Gharavi AG. Genetics of IgA Nephropathy: Insight from the Genetic Studies. Ann Rev Medicine. 2013; 64:339-56.

Kiryluk K., Li Y., Sanna-Cherchi S., et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genetics. 2012; 8(6):e1002765. News

Kiryluk K., Moldoveanu Z., Sanders TJ., et al. Aberrant glycosylation of IgA1 is inherited in pediatric Henoch-Schonlein nephritis. Kidney Int. 2011; 80(1):79-87.

For a full list of publications, please visit Pubmed