Mimi Shirasu-Hiza
Associate Professor
Dept. of Genetics and Development
CUIMC
Curriculum VitaeHome Page
Address:
Tel:
Fax:
E-mail: ms4095@cumc.columbia.edu
I work on circadian-regulated physiologies such as innate immune cell function, metabolism, and sleep in the context of disease using Drosophila as a model organism.
Pubmed Link
Selected Publications:
• Hill VM, O’Connor RM, Sissoko GB, Irobunda IS, Leong S, Canman JC, Shirasu-Hiza M. A bi-directional relationship between sleep and oxidative stress in Drosophila. PLoS Biology 2018 Jul 12;16(7):e2005206. doi: 10.1371/journal.pbio.2005206. PMID: 30001323.
• Lee M, Sitko A, Khalid S, Shirasu-Hiza M, and Mason C. Spatiotemporal distribution of glia in and around the developing mouse optic tract. J of Comp Neurol. 2018 May 9. doi: 10.1002/cne.24462. PMID: 29744881
• O'Connor RM, Stone EF, Wayne CR, Marcinkevicius EV, Ulgherait M., Delventhal R., Pantalia MM, Hill VM, Zhou CG, McAllister S, Chen A, Ziegenfuss JS, Grueber WB, Canman JC, Shirasu-Hiza MM. A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells. Journal of Cell Biology 2017 Mar 6;216(3):595-605. doi: 10.1083/jcb.201607093. Epub 2017 Feb 21.
• Highlighted in J Cell Biol: Logan M. Fragile phagocytes: FMRP positively regulates engulfment activity. J Cell Biol 2017 Feb 22. doi: 10.1083/jcb.201702034
• Selected as Editors’ Choice in Science Signaling: Mushegian A. Impaired phagocytosis in fragile X. Sci Signal. 2017 Apr 4; 10 (473). Doi: 10.1126/scisignal.aan3520
• Ulgherait M, Chen A, Oliva MK, Kim HX, Canman JC, Ja WW, Shirasu-Hiza M. Dietary restriction extends the lifespan of circadian mutants tim and per. Cell Metabolism 2016 Dec 13;24(6):763-764. doi: 10.1016/j.cmet.2016.11.002.
• Allen VW, O’Connor RM, Ulgherait M, Zhou CG, Stone EF, Hill VM, Murphy KR, Canman JC, Ja WW, Shirasu-Hiza MM. period-regulated feeding behavior and TOR signaling modulate survival of infection. Current Biology 2015 Dec 29. pii: S0960-9822(15)01490-6.
• Stone EF, Fulton BO, Ayres JS, Pham LN, Ziauddin J, Shirasu-Hiza MM. The circadian clock protein Timeless regulates phagocytosis of bacteria in Drosophila. PLoS PathogensJan;8(1):e1002445.
• Highlighted in Nature Rev Microbiol 2012 Feb 13;10(3):162.
• Selected by Faculty of 1000