DiGeorge Syndrome Kidney Problems May Be Caused By Missing Gene

NEW YORK, NY (Jan. 25, 2017)—Loss of function of the CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome, a multinational team of scientists led by Columbia University Irving Medical Center (CUIMC) has found. Findings of their study were published online today in the New England Journal of Medicine. “This study represents a […]

A Kidney Disease’s Genetic Clues Are Uncovered

NEW YORK, NY (March 6, 2017)—Researchers have uncovered new genetic clues to understanding IgA nephropathy(link is external and opens in a new window) (IgAN), or Berger’s disease, an autoimmune kidney disease and a common cause of kidney failure. The findings are relevant to IgAN and other diseases with similar underlying molecular defects, such as inflammatory bowel disease […]

Misleading Biopsies May Cause Viable, Donated Kidneys to Be Discarded

Based on biopsy results, thousands of donated kidneys each year are discarded instead of being transplanted, but a new study from physicians at Columbia University Irving Medical Center and NewYork-Presbyterian suggests that biopsies underestimate organ quality. “It’s a complex issue, but our findings suggest that biopsy results should be used not to discard organs, but […]

Kidney Disease Diagnosis May Benefit from DNA Sequencing

New York, NY (Dec. 4, 2017)—DNA sequencing could soon become part of the routine diagnostic workup for patients with chronic kidney disease, suggests a new study from Columbia University Irving Medical Center. The researchers found that DNA sequencing could identify the genetic cause of the disease and influence treatment for many patients with chronic kidney […]

Test to Select Kidneys for Transplant is Often Inaccurate, Study Finds

In brief Results of a biopsy used to help transplant centers select deceased donor kidneys for transplantation are unreliable, according to a new study by physicians at Columbia University Irving Medical Center. Reducing reliance on the biopsy results could greatly increase the number of kidneys available for transplant.  One in five kidneys obtained from deceased […]

For Patients with Kidney Disease, Genetic Testing May Soon Be Routine

A new study(link is external and opens in a new window) has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and that identifying the responsible genes has a direct impact on treatment for most of these patients.  “Our study shows that genetic testing can be used to personalize the diagnosis […]

Genomic Collision May Explain Why Many Kidney Transplants Fail

A genomic collision could explain why many kidney transplants fail, even when donors and recipients are thought to be well-matched, according to a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons. This genomic collision is a genetic incompatibility between kidney donor and recipient, causing the recipient to mount an immune […]

Many Who Die Waiting for a Kidney Had Multiple Offers, New Study Finds

Patients who die waiting for a kidney, or who are removed from the transplant waitlist for poor health, are usually considered unfortunate victims of the ever-growing shortage of available organs. Yet a new study has found that most candidates have had multiple opportunities to receive a transplant, but the offered organs were declined by their transplant team […]

The Pre-History Of The Nephrology Division

By Jay Meltzer, MD Before there was a nephrology division there were only full time faculty doing research in renal physiology and related fields such as endocrinology. These few met once weekly in the Nephritis-Hypertension clinic founded for the treatment of kidney disease and hypertension by Drs. Dana Atchley and Robert F. Loeb. When I […]