The Gharavi lab is pursuing multiple local and multicenter studies to investigate the genetic causes of kidney diseases. We are also conducting several genetic studies generated through the Precision Medicine Initiative. In particular, we are currently enrolling participants in the following studies:
- CureGN study: We are a major site for the CureGN study, an NIH-funded multicenter
five-year cohort study of IgA nephropathy, Focal Segmental
Glomerulosclerosis, Minimal Change Disease and Membranous nephropathy.
We will follow patients longitudinally to better understand the causes
of disease, response to therapy, and disease progression, with the
ultimate objective to cure glomerulopathies.
- Genetics of Chronic Kidney Diseases: The goal of this study is to identify genetic factors predisposing to any kind of chronic kidney diseases. Following an initial focus on IgA nephropathy, Congenital abnormalities of the kidney and the urinary tract (CAKUT) and Vescicouretral reflux (VUR), we will be expanding our areas of interests to a broader spectrum of kidney diseases. This includes any type of glomerular diseases and tubulo-interstitial kidney disease. We are also one of the few centers across the world investigating the pathogenesis of the C3 glomerulopathy and Dense Deposit Disease (DDD), a sub-type of membrano-proliferative glomerulonephritis (MPGN).
- eMERGE Study: The Electronic Medical Records and Genomics (eMERGE) network is a national consortium organized by the National Human Genome Research Institute (NHGRI). The primary goal of the eMERGE Network is to develop, disseminate, and apply approaches to research that combine sample biobanking with electronic medical record systems to improve the discovery of genetic diseases and the implementation of genetic discovery into clinical practice.
All of the aforementioned studies are NIH-funded.
We would like to invite you, your child, or another family member for our study if you have been diagnosed with any kind of kidney disease, in particular if you have one or more of the following conditions:
- Positive family history of kidney disease
- Diagnosis of kidney disease at a young age
- Kidney disease of unknown origin
- Congenital abnormalities of the kidney and the urinary tract (CAKUT) and Vescicouretral reflux (VUR)
- IgAN Nephropathy or Henoch-Schonlein Purpura
- Nephrotic syndrome
- C3 glomerulopathy (C3GN), Dense Deposit Disease (DDD) or membrano-proliferative glomerulonephritis (MPGN)
A signed consent form and a blood sample are required to participate in any of the above studies. Samples can be collected during an in-person appointment or can be shipped to our lab. Also as a part of our studies, we offer free clinic consultations for familial forms of kidney disease.
If you are interested in participating in our studies or have any questions, please contact our project coordinator Maddalena Marasa:
Maddalena Marasa, MD
1150 St. Nicholas Avenue, Rm 413
New York, NY. 10032